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CHAPTER 2: NEOPLASMS (C00-D49) New ICD 10 CM Codes for Inflammatory Breast Cancer C50.A Malignant inflammatory neoplasm of breast (parent code) C50.A0 Malignant inflammatory neoplasm of unspecified breast C50.A1 Malignant inflammatory neoplasm of right breast C50.A2 Malignant inflammatory neoplasm of left breast Revisions C7B.04 Secondary carcinoid tumors of peritoneum C77 Secondary and unspecified malignant neoplasm of lymph nodes D12.6 Benign neoplasm of colon, unspecified D48.11 Desmoid tumor CHAPTER 3: DISEASES OF THE BLOOD AND BLOOD-FORMING ORGANS (D50-D89) New ICD 10 CM Codes - Functional Disorders of Neutrophils D71.1 Leukocyte adhesion deficiency D71.8 Other functional disorders of polymorphonuclear neutrophils D71.9 Functional disorders of polymorphonuclear neutrophils, unspecified Deletions D71 Previously contained terms now redistributed to D71.1, D71.8, and D71.9 Excludes Changes D53.8 Other specified nutritional anemias D68.312 Antiphospholipid antibody with hemorrhagic disorder D68.61 Antiphospholipid syndrome D68.62 Lupus anticoagulant syndrome CHAPTER 4: ENDOCRINE, NUTRITIONAL AND METABOLIC DISEASES (E00-E89) New ICD 10 CM Codes - Diabetes in Remission E11.A Type 2 diabetes mellitus without complications in remission E11.9 Type 2 diabetes mellitus without complications New ICD 10 CM Codes - Hyperoxaluria E72.530 Primary hyperoxaluria, type 1 E72.538 Other specified primary hyperoxaluria E72.539 Primary hyperoxaluria, unspecified E72.540 Dietary hyperoxaluria E72.541 Enteric hyperoxaluria E72.548 Other secondary hyperoxaluria E72.549 Secondary hyperoxaluria, unspecified New ICD 10 CM Codes - Familial Hypercholesterolemia E78.010 Homozygous familial hypercholesterolemia [HoFH] E78.011 Heterozygous familial hypercholesterolemia [HeFH] E78.019 Familial hypercholesterolemia, unspecified New ICD 10 CM Codes - Pyrophosphate Metabolism Disorders E83.820 Generalized arterial calcification of infancy with unspecified genetic causality Code also, if applicable, associated conditions such as: E83.821 ENPP1 deficiency causing generalized arterial calcification of infancy Code also, if applicable, associated conditions such as: E83.822 ENPP1 deficiency causing autosomal recessive hypophosphatemic rickets type 2 E83.823 ABCC6 deficiency causing generalized arterial calcification of infancy Code also, if applicable, associated conditions such as: E83.824 ABCC6 deficiency causing pseudoxanthoma elasticum E83.825 CD73 deficiency causing arterial calcification New ICD 10 CM Codes - Lipodystrophy E88.10 Lipodystrophy, unspecified E88.11 Partial lipodystrophy E88.12 Generalized lipodystrophy E88.13 Localized lipodystrophy E88.14 HIV-associated lipodystrophy E88.19 Other lipodystrophy, not elsewhere classified Instructional Note Changes E27.5 Adrenomedullary hyperfunction NEW Code also, if applicable: E71.540 Rhizomelic chondrodysplasia punctata E72.53 Primary hyperoxaluria E83.3 Disorders of phosphorus metabolism and phosphatases E88.02 Plasminogen deficiency E88.1 Lipodystrophy, not elsewhere classified E88.43 Disorders of mitochondrial tRNA synthetases NEW inclusions: NEW Code also, if applicable: leukoencephalopathy (G93.49) CHAPTER 5: MENTAL, BEHAVIORAL AND NEURODEVELOPMENTAL DISORDERS (F01-F99) Revisions F02 Dementia in other diseases classified elsewhere F42 Obsessive-compulsive disorder F48.2 Pseudobulbar affect F63.2 Kleptomania CHAPTER 6: DISEASES OF THE NERVOUS SYSTEM (G00-G99) New ICD 10 CM Codes - Multiple Sclerosis Subtypes G35.A Relapsing-remitting multiple sclerosis G35.B0 Primary progressive multiple sclerosis, unspecified G35.B1 Active primary progressive multiple sclerosis G35.B2 Non-active primary progressive multiple sclerosis G35.C0 Secondary progressive multiple sclerosis, unspecified G35.C1 Active secondary progressive multiple sclerosis G35.C2 Non-active secondary progressive multiple sclerosis G35.D Multiple sclerosis, unspecified New ICD 10 CM Codes - Other Nervous System Conditions G31.87 Primary progressive apraxia of speech G71.036 Limb girdle muscular dystrophy due to fukutin related protein dysfunction Deletions G35 Multiple sclerosis (old code) DELETED terms: G71.038 Other limb girdle muscular dystrophy DELETED terms: Revisions and Additions G00.1 Pneumococcal meningitis G04 Encephalitis, myelitis and encephalomyelitis G23.3 Hypomyelination with atrophy of the basal ganglia and cerebellum G37.3 Acute transverse myelitis in demyelinating disease of central nervous system G37.9 Demyelinating disease of central nervous system, unspecified G89 Pain, not elsewhere classified CHAPTER 7: DISEASES OF THE EYE AND ADNEXA (H00-H59) New ICD 10 CM Codes - Eyelid Inflammation H01.81 Other specified inflammation of right upper eyelid H01.82 Other specified inflammation of right lower eyelid H01.83 Other specified inflammation of right eye, unspecified eyelid H01.84 Other specified inflammation of left upper eyelid H01.85 Other specified inflammation of left lower eyelid H01.86 Other specified inflammation of left eye, unspecified eyelid H01.89 Other specified inflammation of unspecified eye, unspecified eyelid H01.8A Other specified inflammation of right eye, upper and lower eyelids H01.8B Other specified inflammation of left eye, upper and lower eyelids New ICD 10 CM Codes - Thyroid Orbitopathy H05.831 Thyroid orbitopathy, right orbit H05.832 Thyroid orbitopathy, left orbit H05.833 Thyroid orbitopathy, bilateral H05.839 Thyroid orbitopathy, unspecified orbit H05.83 Thyroid orbitopathy (parent code) Graves ophthalmopathy Graves orbitopathy Thyroid eye disease Code also, if applicable, any associated conditions such as: autoimmune thyroiditis (E06.3) thyrotoxicosis with diffuse goiter (E05.0-) New ICD 10 CM Codes - Neovascular Glaucoma H40.841 Neovascular secondary angle closure glaucoma, right eye H40.842 Neovascular secondary angle closure glaucoma, left eye H40.843 Neovascular secondary angle closure glaucoma, bilateral H40.849 Neovascular secondary angle closure glaucoma, unspecified eye H40.84 Neovascular secondary angle closure glaucoma (parent code) Code first the underlying condition such as: central retinal vein occlusion (H34.81) diabetes mellitus (E08.39, E09.39, E10.39, E11.39, E13.39) retinal ischemia (H35.82) Instructional Note Changes H01.8 Other specified inflammations of eyelid H33.3 Retinal breaks without detachment H35.4 Peripheral retinal degeneration H42 Glaucoma in diseases classified elsewhere H53.03 Strabismic amblyopia CHAPTER 9: DISEASES OF THE CIRCULATORY SYSTEM (I00-I99) New ICD 10 CM Codes - Fontan Related Circulation I27.840 Fontan-associated liver disease [FALD] I27.841 Fontan-associated lymphatic dysfunction Code also associated conditions such as: chylothorax (J94.0) Fontan associated protein-losing enteropathy (K90.89) plastic (obstructive) bronchitis (J44.89) I27.848 Other Fontan-associated condition I27.849 Fontan related circulation, unspecified I27.84 Fontan related circulation (parent code) Instructional Note Changes I51 Complications and ill-defined descriptions of heart disease DELETED from Excludes1, MOVED to Excludes2: any condition in I51.4-I51.9 due to hypertension (I11.-) any condition in I51.4-I51.9 due to hypertension and chronic kidney disease (I13.-) heart disease specified as rheumatic (I00-I09) I51.5 Myocardial degeneration NEW Excludes1: myocardial degeneration due to hypertension (I11.-) myocardial degeneration due to hypertension and chronic kidney disease (I13.-) I51.7 Cardiomegaly NEW Excludes1: cardiomegaly due to hypertension (I11.-) cardiomegaly due to hypertension and chronic kidney disease (I13.-) I70.9 Other and unspecified atherosclerosis I80 Phlebitis and thrombophlebitis CHAPTER 10: DISEASES OF THE RESPIRATORY SYSTEM (J00-J99) Revisions J20 Acute bronchitis J40 Bronchitis, not specified as acute or chronic J43 Emphysema J44 Other chronic obstructive pulmonary disease Changed: Excludes1 Excludes2 for: chronic bronchitis NOS (J42) chronic simple and mucopurulent bronchitis (J41.-) chronic tracheitis (J42) chronic tracheobronchitis (J42) J84.1 Other interstitial pulmonary diseases with fibrosis CHAPTER 11: DISEASES OF THE DIGESTIVE SYSTEM (K00-K95) New Terms/Additions K75.81 Nonalcoholic steatohepatitis (NASH) K76.0 Fatty (change of) liver, not elsewhere classified CHAPTER 12: DISEASES OF THE SKIN AND SUBCUTANEOUS TISSUE (L00-L99) New ICD 10 CM Codes - Flank Injuries L02.217 Cutaneous abscess of flank L02.227 Furuncle of flank L03.31A Cellulitis of flank L03.32A Acute lymphangitis of flank New ICD 10 CM Codes - Non-Pressure Chronic Ulcers Abdomen L98.431 Non-pressure chronic ulcer of abdomen limited to breakdown of skin L98.432 Non-pressure chronic ulcer of abdomen with fat layer exposed L98.433 Non-pressure chronic ulcer of abdomen with necrosis of muscle L98.434 Non-pressure chronic ulcer of abdomen with necrosis of bone L98.435 Non-pressure chronic ulcer of abdomen with muscle involvement without evidence of necrosis L98.436 Non-pressure chronic ulcer of abdomen with bone involvement without evidence of necrosis L98.438 Non-pressure chronic ulcer of abdomen with other specified severity L98.439 Non-pressure chronic ulcer of abdomen with unspecified severity Chest L98.441 Non-pressure chronic ulcer of chest limited to breakdown of skin L98.442 Non-pressure chronic ulcer of chest with fat layer exposed L98.443 Non-pressure chronic ulcer of chest with necrosis of muscle L98.444 Non-pressure chronic ulcer of chest with necrosis of bone L98.445 Non-pressure chronic ulcer of chest with muscle involvement without evidence of necrosis L98.446 Non-pressure chronic ulcer of chest with bone involvement without evidence of necrosis L98.448 Non-pressure chronic ulcer of chest with other specified severity L98.449 Non-pressure chronic ulcer of chest with unspecified severity Neck L98.451 Non-pressure chronic ulcer of neck limited to breakdown of skin L98.452 Non-pressure chronic ulcer of neck with fat layer exposed L98.453 Non-pressure chronic ulcer of neck with necrosis of muscle L98.454 Non-pressure chronic ulcer of neck with necrosis of bone L98.455 Non-pressure chronic ulcer of neck with muscle involvement without evidence of necrosis L98.456 Non-pressure chronic ulcer of neck with bone involvement without evidence of necrosis L98.458 Non-pressure chronic ulcer of neck with other specified severity L98.459 Non-pressure chronic ulcer of neck with unspecified severity Face L98.461 Non-pressure chronic ulcer of face limited to breakdown of skin L98.462 Non-pressure chronic ulcer of face with fat layer exposed L98.463 Non-pressure chronic ulcer of face with necrosis of muscle L98.464 Non-pressure chronic ulcer of face with necrosis of bone L98.465 Non-pressure chronic ulcer of face with muscle involvement without evidence of necrosis L98.466 Non-pressure chronic ulcer of face with bone involvement without evidence of necrosis L98.468 Non-pressure chronic ulcer of face with other specified severity L98.469 Non-pressure chronic ulcer of face with unspecified severity Groin L98.471 Non-pressure chronic ulcer of groin limited to breakdown of skin L98.472 Non-pressure chronic ulcer of groin with fat layer exposed L98.473 Non-pressure chronic ulcer of groin with necrosis of muscle L98.474 Non-pressure chronic ulcer of groin with necrosis of bone L98.475 Non-pressure chronic ulcer of groin with muscle involvement without evidence of necrosis L98.476 Non-pressure chronic ulcer of groin with bone involvement without evidence of necrosis L98.478 Non-pressure chronic ulcer of groin with other specified severity L98.479 Non-pressure chronic ulcer of groin with unspecified severity Upper Limb - Right Upper Arm L98.A111 Non-pressure chronic ulcer of right upper arm limited to breakdown of skin L98.A112 Non-pressure chronic ulcer of right upper arm with fat layer exposed L98.A113 Non-pressure chronic ulcer of right upper arm with necrosis of muscle L98.A114 Non-pressure chronic ulcer of right upper arm with necrosis of bone L98.A115 Non-pressure chronic ulcer of right upper arm with muscle involvement without evidence of necrosis L98.A116 Non-pressure chronic ulcer of right upper arm with bone involvement without evidence of necrosis L98.A118 Non-pressure chronic ulcer of right upper arm with other specified severity L98.A119 Non-pressure chronic ulcer of right upper arm with unspecified severity Upper Limb - Left Upper Arm L98.A121 Non-pressure chronic ulcer of left upper arm limited to breakdown of skin L98.A122 Non-pressure chronic ulcer of left upper arm with fat layer exposed L98.A123 Non-pressure chronic ulcer of left upper arm with necrosis of muscle L98.A124 Non-pressure chronic ulcer of left upper arm with necrosis of bone L98.A125 Non-pressure chronic ulcer of left upper arm with muscle involvement without evidence of necrosis L98.A126 Non-pressure chronic ulcer of left upper arm with bone involvement without evidence of necrosis L98.A128 Non-pressure chronic ulcer of left upper arm with other specified severity L98.A129 Non-pressure chronic ulcer of left upper arm with unspecified severity Upper Limb - Unspecified Upper Arm L98.A191 Non-pressure chronic ulcer of unspecified upper arm limited to breakdown of skin L98.A192 Non-pressure chronic ulcer of unspecified upper arm with fat layer exposed L98.A193 Non-pressure chronic ulcer of unspecified upper arm with necrosis of muscle L98.A194 Non-pressure chronic ulcer of unspecified upper arm with necrosis of bone L98.A195 Non-pressure chronic ulcer of unspecified upper arm with muscle involvement without evidence of necrosis L98.A196 Non-pressure chronic ulcer of unspecified upper arm with bone involvement without evidence of necrosis L98.A198 Non-pressure chronic ulcer of unspecified upper arm with other specified severity L98.A199 Non-pressure chronic ulcer of unspecified upper arm with unspecified severity Upper Limb - Right Forearm L98.A211 Non-pressure chronic ulcer of right forearm limited to breakdown of skin L98.A212 Non-pressure chronic ulcer of right forearm with fat layer exposed L98.A213 Non-pressure chronic ulcer of right forearm with necrosis of muscle L98.A214 Non-pressure chronic ulcer of right forearm with necrosis of bone L98.A215 Non-pressure chronic ulcer of right forearm with muscle involvement without evidence of necrosis L98.A216 Non-pressure chronic ulcer of right forearm with bone involvement without evidence of necrosis L98.A218 Non-pressure chronic ulcer of right forearm with other specified severity L98.A219 Non-pressure chronic ulcer of right forearm with unspecified severity Upper Limb - Left Forearm L98.A221 Non-pressure chronic ulcer of left forearm limited to breakdown of skin L98.A222 Non-pressure chronic ulcer of left forearm with fat layer exposed L98.A223 Non-pressure chronic ulcer of left forearm with necrosis of muscle L98.A224 Non-pressure chronic ulcer of left forearm with necrosis of bone L98.A225 Non-pressure chronic ulcer of left forearm with muscle involvement without evidence of necrosis L98.A226 Non-pressure chronic ulcer of left forearm with bone involvement without evidence of necrosis L98.A228 Non-pressure chronic ulcer of left forearm with other specified severity L98.A229 Non-pressure chronic ulcer of left forearm with unspecified severity Upper Limb - Unspecified Forearm L98.A291 Non-pressure chronic ulcer of unspecified forearm limited to breakdown of skin L98.A292 Non-pressure chronic ulcer of unspecified forearm with fat layer exposed L98.A293 Non-pressure chronic ulcer of unspecified forearm with necrosis of muscle L98.A294 Non-pressure chronic ulcer of unspecified forearm with necrosis of bone L98.A295 Non-pressure chronic ulcer of unspecified forearm with muscle involvement without evidence of necrosis L98.A296 Non-pressure chronic ulcer of unspecified forearm with bone involvement without evidence of necrosis L98.A298 Non-pressure chronic ulcer of unspecified forearm with other specified severity L98.A299 Non-pressure chronic ulcer of unspecified forearm with unspecified severity Upper Limb - Right Hand L98.A311 Non-pressure chronic ulcer of right hand limited to breakdown of skin L98.A312 Non-pressure chronic ulcer of right hand with fat layer exposed L98.A313 Non-pressure chronic ulcer of right hand with necrosis of muscle L98.A314 Non-pressure chronic ulcer of right hand with necrosis of bone L98.A315 Non-pressure chronic ulcer of right hand with muscle involvement without evidence of necrosis L98.A316 Non-pressure chronic ulcer of right hand with bone involvement without evidence of necrosis L98.A318 Non-pressure chronic ulcer of right hand with other specified severity L98.A319 Non-pressure chronic ulcer of right hand with unspecified severity Upper Limb - Left Hand L98.A321 Non-pressure chronic ulcer of left hand limited to breakdown of skin L98.A322 Non-pressure chronic ulcer of left hand with fat layer exposed L98.A323 Non-pressure chronic ulcer of left hand with necrosis of muscle L98.A324 Non-pressure chronic ulcer of left hand with necrosis of bone L98.A325 Non-pressure chronic ulcer of left hand with muscle involvement without evidence of necrosis L98.A326 Non-pressure chronic ulcer of left hand with bone involvement without evidence of necrosis L98.A328 Non-pressure chronic ulcer of left hand with other specified severity L98.A329 Non-pressure chronic ulcer of left hand with unspecified severity Upper Limb - Unspecified Hand L98.A391 Non-pressure chronic ulcer of unspecified hand limited to breakdown of skin L98.A392 Non-pressure chronic ulcer of unspecified hand with fat layer exposed L98.A393 Non-pressure chronic ulcer of unspecified hand with necrosis of muscle L98.A394 Non-pressure chronic ulcer of unspecified hand with necrosis of bone L98.A395 Non-pressure chronic ulcer of unspecified hand with muscle involvement without evidence of necrosis L98.A396 Non-pressure chronic ulcer of unspecified hand with bone involvement without evidence of necrosis L98.A398 Non-pressure chronic ulcer of unspecified hand with other specified severity L98.A399 Non-pressure chronic ulcer of unspecified hand with unspecified severity Revisions L02.212 Cutaneous abscess of back L02.222 Furuncle of back L51 Erythema multiforme L97.2 Non-pressure chronic ulcer of calf Excludes Changes Dermatitis and eczema (L20-L30) section CHAPTER 13: DISEASES OF THE MUSCULOSKELETAL SYSTEM (M00-M99) New Codes M05.A Abnormal rheumatoid factor and anti-citrullinated protein antibody with rheumatoid arthritis Revisions M21.159 Varus deformity, not elsewhere classified, unspecified M24.076 Loose body in unspecified toe joints M61.129 Myositis ossificans progressiva, unspecified arm Instructional Note Changes M36.3 Arthropathy in other blood disorders NEW Code first underlying disease, such as: disease of blood and blood-forming organs, unspecified (D75.9) other hemoglobinopathies (D58.2) thalassemia (D56.-) CHAPTER 14: DISEASES OF THE GENITOURINARY SYSTEM (N00-N99) New ICD 10 CM Codes for Membranoproliferative Glomerulonephritis N00.B1 Acute nephritic syndrome with idiopathic immune membranoproliferative glomerulonephritis (IC-MPGN) N00.B2 Acute nephritic syndrome with secondary immune complex membranoproliferative glomerulonephritis (IC-MPGN) N04.B1 Nephrotic syndrome with idiopathic immune complex membranoproliferative glomerulonephritis (IC-MPGN) N04.B2 Nephrotic syndrome with secondary immune complex membranoproliferative glomerulonephritis (IC-MPGN) New ICD 10 CM Codes for Hereditary Nephropathy N07.B Hereditary nephropathy, not elsewhere classified with APOL1-mediated kidney disease [AMKD] Deletions N00.5 Acute nephritic syndrome with diffuse mesangiocapillary glomerulonephritis N04.5 Nephrotic syndrome with diffuse mesangiocapillary glomerulonephritis Revisions N61 Inflammatory disorders of breast N85.A Isthmocele CHAPTER 15: PREGNANCY, CHILDBIRTH AND THE PUERPERIUM (O00-O9A) Revisions O70.1 Second degree perineal laceration during delivery O70.4 Anal sphincter tear complicating delivery, not associated with third degree laceration O90.4 Postpartum acute kidney failure CHAPTER 16: CERTAIN CONDITIONS ORIGINATING IN THE PERINATAL PERIOD (P00-P96) Revisions P09.6 Abnormal findings on neonatal screening CHAPTER 17: CONGENITAL MALFORMATIONS, DEFORMATIONS, CHROMOSOMAL ABNORMALITIES, AND GENETIC DISORDERS (Q00-QA0) Chapter Title Change Revised from: Congenital malformations, deformations and chromosomal abnormalities (Q00-Q99) Revised to: Congenital malformations, deformations, chromosomal abnormalities, and genetic disorders (Q00-QA0) New Block Added QA0 Genetic disorders, not elsewhere classified New ICD 10 CM Codes for Genetic Syndromes Q87.87 Hao-Fountain Syndrome HAFOUS Use Additional code, if applicable, for associated conditions such as: autism spectrum disorder (F84.0) developmental speech disorder (F80.-) epilepsy, by specific type (G40.-) intellectual disabilities (F70-F79) pervasive developmental disorders (F84.-) Q87.88 CTNNB1 syndrome Use Additional code, if applicable, for associated conditions such as: cerebral palsy (G80.-) congenital heart malformations (Q20.0-Q24.9) developmental disorder of speech and language (F80.-) exudative retinopathy (H35.02-) intellectual disability (F70-F79) microcephaly (Q02) Q89.81 Kabuki syndrome New ICD 10 CM Codes for Usher Syndrome Q99.811 Usher syndrome, type 1 Q99.812 Usher syndrome, type 2 Q99.813 Usher syndrome, type 3 Q99.818 Other Usher syndrome Q99.819 Usher syndrome, unspecified Q99.81 Usher syndrome (parent code) New ICD 10 CM Codes for Neurodevelopmental Disorders (QA0 Section) QA0.0101 SCN2A-related neurodevelopmental disorder QA0.0102 CACNA1A-related neurodevelopmental disorder QA0.0109 Neurodevelopmental disorder related to pathogenic variant in other ion channel gene QA0.0131 SLC6A1-related disorder QA0.0139 Neurodevelopmental disorder, related to pathogenic variant in other transporter or solute carrier gene QA0.0141 Syntaxin-binding protein 1-related disorder QA0.0142 DLG4-related synaptopathy QA0.0149 Neurodevelopmental disorder, related to pathogenic variant in other synapse related gene QA0.0151 FOXG1 syndrome QA0.0159 Neurodevelopmental disorder, related to other genes associated with transcription and gene expression QA0.8 Other neurodevelopmental disorders related to pathogenic variants in other specific genes Revisions Q75.00 Craniosynostosis Q75.001 Revised from: Craniosynostosis unspecified, unilateral Q75.002 Revised from: Craniosynostosis unspecified, bilateral Q75.009 Revised from: Craniosynostosis unspecified Q75.02 Coronal craniosynostosis Q75.021 Revised from: Coronal craniosynostosis unilateral Q75.022 Revised from: Coronal craniosynostosis bilateral Q75.029 Revised from: Coronal craniosynostosis unspecified Q77.3 Chondrodysplasia punctata Instructional Note Changes Q28.8 Other specified congenital malformations of circulatory system Q82.8 Other specified congenital malformations of skin CHAPTER 18: SYMPTOMS, SIGNS AND ABNORMAL CLINICAL AND LABORATORY FINDINGS (R00-R99) New ICD 10 CM Codes for Pelvic and Perineal Pain R10.20 Pelvic and perineal pain unspecified side R10.21 Pelvic and perineal pain right side R10.22 Pelvic and perineal pain left side R10.23 Pelvic and perineal pain bilateral R10.24 Suprapubic pain New ICD 10 CM Codes for Flank Pain and Tenderness R10.A0 Flank pain, unspecified side R10.A1 Flank pain, right side R10.A2 Flank pain, left side R10.A3 Flank pain, bilateral R10.A Pain localized to flank (parent code) R10.8A1 Right flank tenderness R10.8A2 Left flank tenderness R10.8A3 Suprapubic tenderness R10.8A9 Flank tenderness, unspecified R10.85 Abdominal pain of multiple sites Excludes1: abdominal rigidity NOS (R19.3) generalized abdominal pain associated with acute abdomen (R10.0) generalized abdominal pain NOS (R10.84) localized abdominal pain (R10.1-R10.4-) New ICD 10 CM Codes for Costovertebral Tenderness R39.851 Costovertebral (angle) tenderness, right side R39.852 Costovertebral (angle) tenderness, left side R39.853 Costovertebral (angle) tenderness, bilateral R39.859 Costovertebral (angle) tenderness, unspecified side R39.85 Costovertebral (angle) tenderness (parent code) New ICD 10 CM Codes for Cannabis Hyperemesis Syndrome R11.16 Cannabis hyperemesis syndrome Cannabinoid hyperemesis syndrome Code also: cannabis abuse (F12.1-) cannabis dependence (F12.2-) cannabis use, unspecified (F12.92-, F12.93, F12.95-, F12.98-, F12.99) manifestations, such as: dehydration (E86.0) electrolyte imbalance (E87.8) New ICD 10 CM Codes for Abnormal Immunological Findings R76.81 Abnormal rheumatoid factor and anti-citrullinated protein antibody without rheumatoid arthritis R76.89 Other specified abnormal immunological findings in serum Instructional Note Changes R10 Abdominal and pelvic pain R10.1 Pain localized to upper abdomen NEW Excludes2: pain localized to flank (R10.A-) pelvic and perineal pain (R10.2-) R10.2 Pelvic and perineal pain NEW Excludes2: pain localized to other parts of lower abdomen (R10.3-) pain localized to upper abdomen (R10.1-) R10.3 Pain localized to other parts of lower abdomen NEW Excludes2: pain localized to flank (R10.A-) pelvic and perineal pain (R10.2-) R10.81 Abdominal tenderness NEW Excludes2: pain localized to other parts of lower abdomen (R10.3-) pain localized to upper abdomen (R10.1-) R10.82 Rebound abdominal tenderness NEW Excludes2: pain localized to other parts of lower abdomen (R10.3-) pain localized to upper abdomen (R10.1-) R15.0 Incomplete defecation Changed: Excludes1 Excludes2: constipation (K59.0-) fecal impaction (K56.41) R39.12 Poor urinary stream R40.1 Stupor R40.2A Nontraumatic coma due to underlying condition NEW Excludes1: coma scale, best motor response (R40.24.-) coma scale, best verbal response (R40.22.-) coma scale, eyes open (R40.21.-) Glasgow coma scale, total score (R40.23.-) R52 Pain, unspecified R53.8 Other malaise and fatigue R62.51 Failure to thrive (child) R65.21 Severe sepsis with septic shock R69 Illness, unspecified R76.8 Other specified abnormal immunological findings in serum R82.992 Hyperoxaluria Excludes1 revised to: primary hyperoxaluria (E72.53-) [was E72.53] secondary hyperoxaluria (E72.54-) R87.619 Unspecified abnormal cytological findings in specimens from cervix uteri CHAPTER 19: INJURY, POISONING AND CERTAIN OTHER CONSEQUENCES OF EXTERNAL CAUSES (S00-T88) New ICD 10 CM Codes for Flank Injuries (Extensive - Showing Pattern) Contusions S30.11 Contusion of abdominal wall S30.12 Contusion of groin S30.13 Contusion of flank (latus) region Abrasions S30.81A Abrasion of flank Blisters S30.82A Blister (nonthermal) of flank External Constriction S30.84A External constriction of flank Superficial Foreign Body S30.85A Superficial foreign body of flank Insect Bites S30.86A Insect bite (nonvenomous) of flank Other Superficial Bites S30.87A Other superficial bite of flank Unspecified Superficial Injury S30.9A Unspecified superficial injury of flank Open Wounds Without Penetration - Right Flank S31.106 Unspecified open wound of abdominal wall, right flank without penetration into peritoneal cavity S31.116 Laceration without foreign body of abdominal wall, right flank without penetration into peritoneal cavity S31.126 Laceration with foreign body of abdominal wall, right flank without penetration into peritoneal cavity S31.136 Puncture wound of abdominal wall without foreign body, right flank without penetration into peritoneal cavity S31.146 Puncture wound of abdominal wall with foreign body, right flank without penetration into peritoneal cavity S31.156 Open bite of abdominal wall, right flank without penetration into peritoneal cavity Open Wounds Without Penetration - Left Flank S31.107 Unspecified open wound of abdominal wall, left flank without penetration into peritoneal cavity S31.117 Laceration without foreign body of abdominal wall, left flank without penetration into peritoneal cavity S31.127 Laceration with foreign body of abdominal wall, left flank without penetration into peritoneal cavity S31.137 Puncture wound of abdominal wall without foreign body, left flank without penetration into peritoneal cavity S31.147 Puncture wound of abdominal wall with foreign body, left flank without penetration into peritoneal cavity S31.157 Open bite of abdominal wall, left flank without penetration into peritoneal cavity Open Wounds Without Penetration - Unspecified Flank S31.10A Unspecified open wound of abdominal wall, unspecified flank without penetration into peritoneal cavity S31.11A Laceration without foreign body of abdominal wall, unspecified flank without penetration into peritoneal cavity S31.12A Laceration with foreign body of abdominal wall unspecified flank without penetration into peritoneal cavity S31.13A Puncture wound of abdominal wall without foreign body, unspecified flank without penetration into peritoneal cavity S31.14A Puncture wound of abdominal wall with foreign body, unspecified flank without penetration into peritoneal cavity S31.15A Open bite of abdominal wall, unspecified flank without penetration into peritoneal cavity Open Wounds With Penetration - Right Flank S31.606 Unspecified open wound of abdominal wall, right flank with penetration into peritoneal cavity S31.616 Laceration without foreign body of abdominal wall, right flank with penetration into peritoneal cavity S31.626 Laceration with foreign body of abdominal wall, right flank with penetration into peritoneal cavity S31.636 Puncture wound of abdominal wall without foreign body, right flank with penetration into peritoneal cavity S31.646 Puncture wound of abdominal wall with foreign body, right flank with penetration into peritoneal cavity S31.656 Open bite of abdominal wall, right flank with penetration into peritoneal cavity Open Wounds With Penetration - Left Flank S31.607 Unspecified open wound of abdominal wall, left flank with penetration into peritoneal cavity S31.617 Laceration without foreign body of abdominal wall, left flank with penetration into peritoneal cavity S31.627 Laceration with foreign body of abdominal wall, left flank with penetration into peritoneal cavity S31.637 Puncture wound of abdominal wall without foreign body, left flank with penetration into peritoneal cavity S31.647 Puncture wound of abdominal wall with foreign body, left flank with penetration into peritoneal cavity S31.657 Open bite of abdominal wall, left flank with penetration into peritoneal cavity Open Wounds With Penetration - Unspecified Flank S31.60A Unspecified open wound of abdominal wall, unspecified flank with penetration into peritoneal cavity S31.61A Laceration without foreign body of abdominal wall, unspecified flank with penetration into peritoneal cavity S31.62A Laceration with foreign body of abdominal wall, unspecified flank with penetration into peritoneal cavity S31.63A Puncture wound of abdominal wall without foreign body, unspecified flank with penetration into peritoneal cavity S31.64A Puncture wound of abdominal wall with foreign body, unspecified flank with penetration into peritoneal cavity S31.65A Open bite of abdominal wall, unspecified flank with penetration into peritoneal cavity New ICD 10 CM Codes for Fluoroquinolone Poisoning T36.AX1 Poisoning by fluoroquinolone antibiotics, accidental (unintentional) T36.AX2 Poisoning by fluoroquinolone antibiotics, intentional self-harm T36.AX3 Poisoning by fluoroquinolone antibiotics, assault T36.AX4 Poisoning by fluoroquinolone antibiotics, undetermined T36.AX5 Adverse effect of fluoroquinolone antibiotics T36.AX6 Underdosing of fluoroquinolone antibiotics New ICD 10 CM Codes for Xylazine Toxicity T65.841 Toxic effect of xylazine, accidental (unintentional) T65.842 Toxic effect of xylazine, intentional self-harm T65.843 Toxic effect of xylazine, assault T65.844 Toxic effect of xylazine, undetermined T65.84 Toxic effect of xylazine (parent code) Use Additional code(s) for all associated manifestations, such as: cellulitis and acute lymphangitis (L03.-) cutaneous abscess, furuncle and carbuncle (L02.-) non-pressure chronic ulcer of lower limb, not elsewhere classified (L97.-) non-pressure chronic ulcer of skin, not elsewhere classified (L98.4-) New ICD 10 CM Codes for War Theater Effects T75.830 Gulf war illness T75.838 Effects of other war theater T75.83 Effects of war theater (parent code) New ICD 10 CM Codes for Milk Allergy with Baked Milk Tolerance T78.070 Anaphylactic reaction due to milk and dairy products with tolerance to baked milk T78.071 Anaphylactic reaction due to milk and dairy products with reactivity to baked milk T78.079 Anaphylactic reaction due to milk and dairy products, unspecified New ICD 10 CM Codes for Egg Allergy with Baked Egg Tolerance T78.080 Anaphylactic reaction due to egg with tolerance to baked egg T78.081 Anaphylactic reaction due to egg with reactivity to baked egg T78.089 Anaphylactic reaction due to eggs, unspecified New ICD 10 CM Codes for Other Adverse Food Reactions T78.110 Other adverse food reactions due to milk and dairy products with tolerance to baked milk T78.111 Other adverse food reaction due to milk and dairy products with reactivity to baked milk T78.119 Other adverse food reaction due to milk and dairy products with baked milk tolerance/reactivity, unspecified T78.120 Other adverse food reaction due to egg with tolerance to baked egg T78.121 Other adverse food reaction due to egg with reactivity to baked egg T78.129 Other adverse food reaction due to egg with baked egg tolerance/reactivity, unspecified T78.19 Other adverse food reactions, not elsewhere classified Revisions S12.8 Fracture of other parts of neck S30.1 Contusion of abdominal wall S37.6 Injury of uterus S62.9 Unspecified fracture S62.90 Revised from: Unspecified fracture of unspecified wrist and hand S62.91 Revised from: Unspecified fracture of right wrist and hand S62.92 Revised from: Unspecified fracture of left wrist and hand S74.21 Injury of cutaneous sensory nerve at hip and thigh level, right leg CHAPTER 20: EXTERNAL CAUSES OF MORBIDITY (V00-Y99) New ICD 10 CM Codes for Blast Overpressure War Operations Y36.A1 Low level blast overpressure in war operations Y36.A2 High level blast overpressure in war operations Y36.A Blast overpressure in war operations (parent code) Code also type of explosive, if known: accidental detonation of onboard munitions (Y36.140) explosion of grenade (Y36.290) explosion of torpedo (Y36.040) improvised explosive device (Y36.230) Military Operations Y37.A1 Low level blast overpressure in military operations Y37.A2 High level blast overpressure in military operations Y37.A Blast overpressure in military operations (parent code) Code also type of explosive, if known: accidental detonation of onboard munitions (Y37.140) explosion of grenade (Y37.290) explosion of torpedo (Y37.040) improvised explosive device (Y37.230) New ICD 10 CM Codes for Activity Codes Y93.L1 Activity, splitting wood Y93.L9 Activity, other outdoor activity New ICD 10 CM Codes for Foreign Body Entry W44.H9 Other sharp object entering into or through a natural orifice W45.3 Fishing hook entering through skin Revisions V06.938 Pedestrian on other standing micro-mobility pedestrian conveyance injured in collision with other nonmotor vehicle W44.A9 Other batteries entering into or through a natural orifice Y07.435 Stepbrother, perpetrator of maltreatment and neglect CHAPTER 21: FACTORS INFLUENCING HEALTH STATUS AND CONTACT WITH HEALTH SERVICES (Z00-Z99) New ICD 10 CM Codes for Genetic Susceptibility Z15.05 Genetic susceptibility to malignant neoplasm of fallopian tube(s) Z15.060 Genetic susceptibility to colorectal cancer Z15.068 Genetic susceptibility to other malignant neoplasm of digestive system Z15.07 Genetic susceptibility to malignant neoplasm of urinary tract Z15.3 Genetic susceptibility to kidney disease New ICD 10 CM Codes for Prophylactic Surgery Z40.81 Encounter for prophylactic surgery for removal of ovary(s) for persons without known genetic/familial risk factors Z40.82 Encounter for prophylactic surgery for removal of fallopian tube(s) for persons without known genetic/familial risk factors Z40.89 Encounter for other prophylactic surgery New ICD 10 CM Codes for Employment Issues Z56.6 Other physical and mental strain related to work Z56.89 Other problems related to employment NEW inclusions: Furloughed Underemployed New ICD 10 CM Codes for Housing and Economic Issues Z59.02 Unsheltered homelessness Z59.12 Inadequate housing utilities Z59.19 Other inadequate housing Z59.861 Financial insecurity, difficulty paying for utilities Z59.868 Other specified financial insecurity Z59.869 Financial insecurity, unspecified New ICD 10 CM Codes for War Theater Exposure Z77.31 Contact with and (suspected) exposure to Gulf War theater Z77.39 Contact with and (suspected) exposure to other war theater New ICD 10 CM Codes for Family History Z80.44 Family history of malignant neoplasm of fallopian tube(s) Z84.11 Family history of APOL1-mediated kidney disease [AMKD] Z84.19 Family history of other disorders of kidney and ureter Z84.A Family history of exposure to diethylstilbestrol New ICD 10 CM Codes for Personal History Z85.4A Personal history of malignant neoplasm of fallopian tube(s) Z86.00A Personal history of in-situ neoplasm of the fallopian tube(s) New ICD 10 CM Codes for Allergy to Milk with Baked Milk Tolerance Z91.0110 Allergy to milk products, unspecified Z91.0111 Allergy to milk products with tolerance to baked milk Z91.0112 Allergy to milk products with reactivity to baked milk New ICD 10 CM Codes for Allergy to Eggs with Baked Egg Tolerance Z91.0120 Allergy to eggs, unspecified Z91.0121 Allergy to eggs with tolerance to baked egg Z91.0122 Allergy to eggs with reactivity to baked egg New ICD 10 CM Codes for DES Exposure Z91.B Personal risk factor of exposure to diethylstilbestrol DES daughter or son Personal risk factor of exposure to DES Personal risk factor of exposure to DES in utero Second generation DES exposure Code also, associated conditions, such as: conditions classifiable to C50.- osteoporosis (M80.-) premature menopause (E28.31-) Instructional Note Changes Z00-Z13 Persons encountering health services for examinations Z01 Encounter for other special examination without complaint Z40.0 Encounter for prophylactic surgery for risk factors related to malignant neoplasms Z40.02 Encounter for prophylactic removal of ovary(s) Z59.819 Housing instability, housed unspecified Z59.86 Financial insecurity Z59.87 Material hardship due to limited financial resources, not elsewhere classified Z83.718 Family history of other colon polyps Z87.41 Personal history of dysplasia of the female genital tract Z98 Other postprocedural states Z99.11 Dependence on respirator [ventilator] status How to Access Complete Code Files CMS Website: Download These Files: 2026 ICD-10-CM Addendum (ZIP file containing): Table 6A: New diagnosis codes Table 6C: Invalid/deleted diagnosis codes Table 6E: Revised diagnosis codes 2026 ICD-10-CM Guidelines (PDF) 2026 ICD-10-CM Code Descriptions in Tabular Order

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